Interesting, yet stupid, idea...
Keep in mind that there may be a loopback in the ISA slot to keep the channel working, so taking the slot out could render the motherboard useless... And if you wanted to put it back in in the future you'll need to remember which end went where for the same reason...
I say to just leave it there as you can render your hardware useless; i mean it's not like you have a clear case like IceMyst does

...
IF you do decide to do this keep in mind that you will be voiding your warrenty as well as keep in mind you will need to get rid of every last speck of solder around the ISA port as well...